Jadwal Liga Inggris
| September 25, 2021 | ||
| Chelsea | 18:30 | Manchester City |
| Manchester United | 18:30 | Aston Villa |
| Everton | 21:00 | Norwich City |
| Leeds United | 21:00 | West Ham United |
| Leicester City | 21:00 | Burnley |
| Watford | 21:00 | Newcastle United |
| Brentford | 23:30 | Liverpool |
| September 26, 2021 | ||
| Southampton | 20:00 | Wolverhampton Wanderers |
| Arsenal | 22:30 | Tottenham Hotspur |
| September 28, 2021 | ||
| Crystal Palace | 02:00 | Brighton & Hov… |
| Oktober 2, 2021 | ||
| Manchester United | 18:30 | Everton |
| Wolverhampton Wanderers | 21:00 | Newcastle United |
| Burnley | 21:00 | Norwich City |
| Leeds United | 21:00 | Watford |
| Chelsea | 21:00 | Southampton |
| Brighton & Hov… | 23:30 | Arsenal |
| Oktober 3, 2021 | ||
| Crystal Palace | 20:00 | Leicester City |
| Tottenham Hotspur | 20:00 | Aston Villa |
| West Ham United | 20:00 | Brentford |
| Liverpool | 22:30 | Manchester City |
Hasil Liga Inggris
| September 19, 2021 | ||
| Tottenham Hotspur | 0 - 3 | Chelsea |
| West Ham United | 1 - 2 | Manchester United |
| Brighton & Hov… | 2 - 1 | Leicester City |
| September 18, 2021 | ||
| Aston Villa | 3 - 0 | Everton |
| Norwich City | 1 - 3 | Watford |
| Manchester City | 0 - 0 | Southampton |
| Liverpool | 3 - 0 | Crystal Palace |
| Burnley | 0 - 1 | Arsenal |
| Wolverhampton Wanderers | 0 - 2 | Brentford |
| Newcastle United | 1 - 1 | Leeds United |
| September 14, 2021 | ||
| Everton | 3 - 1 | Burnley |
| September 12, 2021 | ||
| Leeds United | 0 - 3 | Liverpool |
| September 11, 2021 | ||
| Chelsea | 3 - 0 | Aston Villa |
| Watford | 0 - 2 | Wolverhampton Wanderers |
| Southampton | 0 - 0 | West Ham United |
| Manchester United | 4 - 1 | Newcastle United |
| Leicester City | 0 - 1 | Manchester City |
| Brentford | 0 - 1 | Brighton & Hov… |
| Arsenal | 1 - 0 | Norwich City |
| Crystal Palace | 3 - 0 | Tottenham Hotspur |
