Jadwal Liga Inggris
| September 23, 2021 | ||
| Sampdoria | 23:30 | SSC Napoli |
| Torino | 23:30 | Lazio |
| September 24, 2021 | ||
| Roma | 01:45 | Udinese |
| September 25, 2021 | ||
| Spezia | 20:00 | AC Milan |
| Inter Milan | 23:00 | Atalanta |
| September 26, 2021 | ||
| Genoa | 01:45 | Verona |
| Juventus | 17:30 | Sampdoria |
| Empoli | 20:00 | Bologna |
| Sassuolo | 20:00 | Salernitana |
| Udinese | 20:00 | Fiorentina |
| Lazio | 23:00 | Roma |
| September 27, 2021 | ||
| SSC Napoli | 01:45 | Cagliari |
| September 28, 2021 | ||
| Venezia | 01:45 | Torino |
| Oktober 2, 2021 | ||
| Cagliari | 01:45 | Venezia |
| Salernitana | 20:00 | Genoa |
| Torino | 23:00 | Juventus |
| Oktober 3, 2021 | ||
| Sassuolo | 01:45 | Inter Milan |
Hasil Liga Inggris
| September 23, 2021 | ||
| AC Milan | 2 - 0 | Venezia |
| Cagliari | 0 - 2 | Empoli |
| September 22, 2021 | ||
| Spezia | 2 - 3 | Juventus |
| Salernitana | 2 - 2 | Verona |
| Fiorentina | 1 - 3 | Inter Milan |
| Atalanta | 2 - 1 | Sassuolo |
| September 21, 2021 | ||
| Bologna | 2 - 2 | Genoa |
| Udinese | 0 - 4 | SSC Napoli |
| September 20, 2021 | ||
| Juventus | 1 - 1 | AC Milan |
| September 19, 2021 | ||
| Verona | 3 - 2 | Roma |
| Lazio | 2 - 2 | Cagliari |
| Venezia | 1 - 2 | Spezia |
| Empoli | 0 - 3 | Sampdoria |
| Salernitana | 0 - 1 | Atalanta |
| September 18, 2021 | ||
| Inter Milan | 6 - 1 | Bologna |
| Genoa | 1 - 2 | Fiorentina |
| Sassuolo | 0 - 1 | Torino |
| September 14, 2021 | ||
| Bologna | 1 - 0 | Verona |
